Category Archives: Genetics

MUSINGS FOR SUNDAY 24TH, FEBRUARY 2019

“If an AI possessed any one of these skills—social abilities, technological development, economic ability—at a superhuman level, it is quite likely that it would quickly come to dominate our world in one way or another. And as we’ve seen, if it ever developed these abilities to the human level, then it would likely soon develop them to a superhuman level. So we can assume that if even one of these skills gets programmed into a computer, then our world will come to be dominated by AIs or AI-empowered humans.”
― Stuart Armstrong,
Smarter Than Us: The Rise of Machine Intelligence

“A powerful AI system tasked with ensuring your safety might imprison you at home. If you asked for happiness, it might hook you up to a life support and ceaselessly stimulate your brain’s pleasure centers. If you don’t provide the AI with a very big library of preferred behaviors or an ironclad means for it to deduce what behavior you prefer, you’ll be stuck with whatever it comes up with. And since it’s a highly complex system, you may never understand it well enough to make sure you’ve got it right.”
― James Barrat,
Our Final Invention: Artificial Intelligence and the End of the Human Era

“Why give a robot an order to obey orders—why aren’t the original orders enough? Why command a robot not to do harm—wouldn’t it be easier never to command it to do harm in the first place? Does the universe contain a mysterious force pulling entities toward malevolence, so that a positronic brain must be programmed to withstand it? Do intelligent beings inevitably develop an attitude problem? Now that computers really have become smarter and more powerful, the anxiety has waned. Today’s ubiquitous, networked computers have an unprecedented ability to do mischief should they ever go to the bad. But the only mayhem comes from unpredictable chaos or from human malice in the form of viruses. We no longer worry about electronic serial killers or subversive silicon cabals because we are beginning to appreciate that malevolence—like vision, motor coordination, and common sense—does not come free with computation but has to be programmed in. Aggression, like every other part of human behavior we take for granted, is a challenging engineering problem!”
― Steven Pinker,
How the Mind Works

This picture was taken on Sunday the 10th of February, looking North. It was a cold evening and air quality was just on the edge of the acceptable range. Not much air movement due to no wind. You can just make out some of the brown cloud that plagues the Front Range of Colorado. It does make for a beautiful sunset. LOL. Still a nice run during the afternoon. Saw a couple of healthy looking Coyotes on this trail run. I am guessing that they have been feeding on the plethora of rabbits in the area.

Well it has been a great two weeks I think. The weather has been cold and snowy, off and on here on the Front Range, but not enough to really make much of a difference with running. The snow in the mountains has been wonderful and the best part, it has continued to come down. I have gotten in a couple of days of skiing and both of those days were great. Excellent conditions compared to last year.

This picture was taken on Thursday 14th, February 2019 while walking with Janet. We have heard owls in this area quit a bit, but had not seen one this close up. It was pretty cool to say the least to see the bird hooting. The whole body was involved in producing the hoot. It was easy to identify the species on this one. A Great Horned Owl. LOL. Looking at this picture now, I can see why the Native Americans and early settlers made up stories about these birds. It does look a little creepy. Again, a cold afternoon walk but the bike path was clear of ice and snow and with some wind, the air quality levels were much better.

As some may know we lost our white German Shepherd Neige, back last August. She had Degenerative Myelopathy. A genetically inherited malady that is a progressive, incurable disease of the spinal cord in dogs. Similar to ALS in humans. To say that we were heart broken would be an understatement. But as they say, time heals all wounds. So we have started to look again for a dog. I think that we are going to stick with the German Shepherd breed. But it has been hard to say the least. We have owned four Shepherds in the last 30 years and they have all suffered some form of the most common genetic aliments of the breed. Neige lived to be 12 years old and was definitely enough dog for two people. Meaning that we had not really looked at what is out there in the market place for a while.

Neige in better times. Doing what she loved to do. This picture was taken about a year ago, last March 2018. Thinking back, wondering if I was in a hurry that day? Could I have thrown her the stick a few more times knowing what I know now…. Time is a lot shorter than you ever realize…. Always loved and never forgotten….

So I have been doing a little bit of “dog” research and my conclusions, “It is all about genetic testing.” First if you buy from a breeder – then you need genetic testing of the parents to rule out some of the common genetic ailments. Otherwise it is just a game of roulette, no matter what the breeder tells you. And if you decided to get one from the humane society or shelter of your choice – then you need to do some, you guessed it, genetic testing. A little more difficult to do when the dog is from the shelter. But possible, just not convenient. I found it interesting that some of the shelters are now starting to do this on their own. They have found that it makes some dogs much more adoptable to know the breed mixes in the dog and (for an added cost) if they are susceptible to certain common genetic diseases. If you think about how much time, effort, and money you put into a family pet. Not to mention, they truly become part of your family. And in some cases a very significant part of your life. I think it makes sense to go a step further in the selection process and do the genetic testing. Especially now that the technology to do this is available and has come down significantly in price. For me, it just makes sense to do it. I know that this will be a little controversial with a few people and that is OK. I hope it generates some good discussion and consideration the next time you look for a dog. A good recent article on this subject is from WIRED magazine: https://www.wired.com/story/dog-dna-kits-reviewed/?mbid=email_onsiteshare

This picture was taken Saturday 16th, February 2019, looking North West in the late afternoon. I have to say it was a beautiful sunset. Cold, in the teens, with a little wind. In Colorado we get what is know as “standing wave clouds” and this is an example. They can make for great sunset pictures. The colors do not last for long but can be quit intense for a few minutes.

Now on a totally different note, I have started to listen to a new audio book called “Life 3.0 – Being Human in the Age of Artificial Intelligence” by Max Tegmark. I am not very far into it yet but it really has gotten me thinking about A.I. and what that means for the future of humanity. Tegmark is a is a Swedish-American physicist and cosmologist. He is a professor at the Massachusetts Institute of Technology and the scientific director of the Foundational Questions Institute. I have read a previous book from him called “Our Mathematical Universe.” I am only a few chapters into the new book but I am already feeling that the true game changer for Humanity, good or bad, may be the development of an Advanced A.I. It might not even need to be “sentient” as in human terms to be this game changer.

You can find the book on Amazon at: https://www.amazon.com/Life-3-0-Being-Artificial-Intelligence/dp/B0742JQF31/ref=sr_1_1?ie=UTF8&qid=1550651814&sr=8-1&keywords=life+3.0+being+human+in+the+age+of+artificial+intelligence

We are becoming so complex as a society, billions and billions of people on the planet. There are some estimates that we will reach the 10 billion mark by 2030. With this many people we will have become, a true global community on a scale never known in human history, with all our usual human wants and needs. Resource allocation will not be something that can be left to chance. Housing, work, travel, food, medical care, security, energy, clean air/water, education, news, entertainment, social media, solitude, etc… will all have to be coordinated to a degree that we have never seen as a species. Second and Third world countries will continue to want to move up the ladder of prosperity and have all the things that you and I now take for granted. Just thinking about that, gives me chills. It will be a daunting task….. How will all this “complexity” be managed and coordinated? What “algorithm” will be sophisticated enough to help us deal with it all? My belief and others is that this increasing complexity of a burgeoning human population will give rise to a super intelligent A.I. Not a matter of if, but when. The big question that comes with this, is how do we want it to occur and who to manage it. Do we want society to become an Orwellian/Kafkaesque Dystopia? Big brother always watching, judging, today’s freedoms severely curtailed? Or the filling out of forms, after forms, after forms, after forms, in order to just buy a car, get married, go on a simple vacation, or even just traveling across state lines? Is there a better way?

Personally I don’t think this will take 100 years. I would not be surprised if it happened in the next 20.

A.I. or more importantly,the people that control A.I. will have the ability to push society to change, but will it be in the right directions. To give us more freedoms, to give us better and/or cheaper housing, work, travel, food, medical care, security, energy, clean air/water, education, news, etc… and advances in technology that makes today’s tech seem like rubbing two sticks together to make fire. This is what Tegmark talks about in his new book with the hope that he can get people from all walks of life involved in the discussion of A.I. His belief is that this will be one of, if not the “Monumental” question of the 21st century. I have not totally finished reading it yet but from what I have read so far, I felt it was important to put a partial review out. I highly recommend the book.

This picture was taken Saturday 23rd, February 2019. What a beautiful Colorado day! Sunny, cold but not too cold. Temp about 32 degrees F in the parking lot, and best of all there was some wind. So most of the brown cloud was gone. This picture was taken in Horsetooth Mountain Park looking South to South East. That horizon is at least 50 miles from where I am standing. Someday as we move away from fossil fuels, this might be the norm again and not just the exception.

Well I think that I am about done for this Blog post. I hope the last two weeks have been great for you dear reader. Remember your comments are always welcome. Take care and maybe I will see you out there on the trail or the ski slope. Adios amigos!!

MUSINGS FOR SATURDAY 19TH, MAY 2018

“Life is good, bad, beautiful and ugly…but it is all experience, so drink it up and guzzle it down my friends, for it is all we are given.”  EB

Well another good week.  RAN the Quad Rock 25 and not the 50 last Saturday and that was an experience…  This was my forth time to run the 25.  And each time it has been different.  This year was no exception.  True to course the weather did not fully cooperate….  Yes it was cool (good for running), yes it did not rain hard (just a light mist), yes there was really no wind, and all of this was fantastic for running…. but it made up for these by giving us runners and spectators a taste of MUD…. REAL MUD!!  Not quite the “Wrath of God” type of mud but close to it.

I have never had the experience of running in mud like this for a long distance.  And what I learned:  It is one thing to just run a mile or two in mud but quite something else to find it on about 40 percent of the course.  Now I am probably exaggerating a little bit because when you are out there in it….  Well it just seemed like it was everywhere.

Think of chocolate cake icing about 3 to 6 inches deep.  Slippery, somewhat sticky to real sticky, and did I say slippery… you get the trail conditions.  Halfway through the first 25-mile lap I was already thinking that one lap of this Mud Fest was enough.  I am a “slow runner” and my best time for this course is 6 hours and 10 minutes.  This year’s mud slowed me down enough that I finished the first lap in 7 hours and 30 minutes.  An hour and 20 minutes longer…. Oh well, that is what I am blaming it on.  It is all EXPERIENCE.

A big THANK YOU to all the volunteers that hung out in the cold and wet.  Without your help and dedication this would have been a much less enjoyable race.  And a shout out to GNAR runners for putting on the Quad Rock.  As always, they put on a great show, no matter the weather.   Will I be back next year??  Absolutely!!  Will I be shooting for the 50 again??  You bet!!

 

Well on a different note this week, I noticed that I have been using an app on my phone to track my calories and food choices among other things, called Lose it!  I have been using the app for about three to four years now. And for me, this is a long time to be using the same phone app.  Wow!  Now you would think my first thought would be I really like this app.  But you would be wrong…my first thought was “WTF” – Where did the time go!!  The “really like part” came as the second thought….

Now, you may be wondering if I have been that “anal” to log every calorie and food choice since I first started using the app….  The answer is no, a resounding no, but at the same time it has really helped me to see trends in how and what I eat and where I could do better.  It can tell me how many calories for the day or week, what are the ratios of fats to carbohydrates and protein.  And one that I have really started to pay more attention to but is not directly related to nutrition.  That one is sleep.  A good way over time to see what your averages are for sleep which can lead to better recovery after those long trail runs.

One of the best features with this app is that it syncs with several other programs.  As an example:  It syncs with Strava, which syncs with Movescount (Suunto Watches) so that my exercise data transfers over in calories burned for the day.  It has helped me to lose about 20lbs since I started ultra-running.  When I turned 50 I was right at 183lbs.  Then over the course of a year I lost down to about 155lbs but became stuck.  I stayed at this weight for about two years.  I would gain a little bit, then lose a little bit.  A kind of Yoyoing back and forth.  Which became very frustrating.

Then I discovered the Lose It app.  Which allowed the better tracking of calories and helped me to drop another 20 lbs.  But, it was not just about the tracking of calories that helped, it was the amount of protein, fat and carbs and the ensuing “change of habits” that really helped.  One of the things that astonishes me now and still does at times, is the amount of food you can put away if you are not being a little more mindful.  As an example, I would come home from work (working night shift) and think nothing of adding a “small snack” before going to bed.  When I started tracking this, the small snack was anywhere from 500 to well over 1000 calories!! Do this a few nights every week and it adds up…. Way up…. It also can give you calories for various types of day to day activity or you can add it after looking up calories burned for a specific activity.   There are also informational sections of the app about food and nutrition.

The developers have recently added one on genetics called embodyDNA.  If you have already had your DNA sequenced by Helix, the National Geographic sponsored one, then for an extra 50 bucks embodyDNA will use it to let you know things about DNA-based insights on BMI, Low Fat Diets, Saturated Fat, Sugar, Exercise and Nutrition.  Also, possible sensitivities like lactose tolerance, gluten tolerance and caffeine metabolism.  I think if you want to get serious about your nutrition and create a food environment to let your body run as efficiently as possible this is one way to do it.   Here is the link to the Lose It! Website:  http://www.loseit.com/  and the embodyDNA site:  https://embodydna.com/

Check them out and let me know what you think!!  Well that is all for this week.  See ya next Friday.  First Columbine Flower for the yard bloomed a few days ago.  Always beautiful.